MucoPAP – assaying Cystic Fibrosis

The Pancreatitis-associated protein (PAP) is synthesized in pancreas during pancreatic stress. In cystic fibrosis (CF), the pancreas is already diseased in utero and PAP is synthesized before birth. Several studies have shown that PAP concentration is indeed elevated in the blood of CF newborns. A synthesis of these works was carried out by the HAS (Haute Autorité de Santé) in 2015 (cf. pdf).

PAP assay on calibrated screening cards allows detection of newborns at risk of developing cystic fibrosis.

Dynabio has developped a range of products for cystic fibrosis neonatal screening: it includes three assay kits whose main differences are listed int the table below:

Kits Assay

MucoPAP

MucoPAPII

MucoPAP-F

Standard range

Lyophilized

Calibrated screening cards

Calibrated screening cards

Controls

Number

1

3

3

Type

Lyophilized

Calibrated screening cards

Calibrated screening cards

Revelation method

ELISA

ELISA

TRF

Shelflife (months)

6

6

12

PAP Assay Kits

PancrePAP Kit
MucoPAP Kit
MucoPAP-II Kit
MucoPAP-F Kit