PancrePAP assay kit

The Pancreatitis Associated Protein (PAP) is synthesized by the exocrine pancreas in the course of acute pancreatitis. It is found in the blood within 12 hours of the onset of the pancreatitis episode. A multicenter study in the adult (Gastroenterology, 1994,106 : 728-734) has shown that :

  • Patients presenting with a normal serum PAP value at admission generally do not develop complications. The range of normal serum PAP concentrations is 0-10 ng/ml ( of the variations of the serum PAP level in a patient provides information on the progression of acute pancreatitis. A kit for assaying PAP by ELISA, called PancrePAP is available from DYNABIO. The kit allows PAP assay in human serum or plasma. It contains all reagents for 96 PAP assays a median 12.5 ng/ml)

  • An increase with time of serum PAP concentration reflects a progression of the disease.

  • A decrease indicates that the acute phase of the crisis is ending.

Thus, analysis of the variations of the serum PAP level in a patient provides information on the progression of acute pancreatitis.

In oncology, in the case of pancreatic ductal adenocarcinoma (n = 251), it has been shown (Cell. Mol. Life Sci, 2017, 74 :4231-4243) that:

  • the overall disease-free survival is significantly reduced in patients presenting a serum PAP level higher than 17.5 ng/mL in comparison to patients presenting a serum PAP level lower than 17.5 ng/mL;

  • patients presenting a serum PAP level higher than 17.5 ng/mL have a reduced overall survival after surgery compared to patients presenting a serum PAP level lower than 17.5 ng/mL.

These data suggest a clinical correlation between an elevated serum PAP concentration and a poor prognosis in patients affected by pancreatic ductal adenocarcinoma, even for the ones who underwent surgery

A kit for assaying PAP by ELISA, called PancrePAP is available from DYNABIO.

The kit allows PAP assay in human serum or plasma. It contains all reagents for 96 PAP assays and instructions for use. Its shelf life is 6 months.

 

The microtitration plate contains six 16-well bars, which can be used independently if a few assays have to be made at a time. 

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PancrePAP

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